Charlotte’s Web is a cannabidiol (CBD) forward strain that was developed for the purpose of alleviating a young girl’s epilepsy. CBD strains have also been known to relieve anxiety and depression, but only for certain people. Perhaps only benefiting half of a crucial system is the reason. This system helps to regulate your eat, sleep, and protect instincts.

It is called the endocannabinoid system. Other cannabinoids, like cannabigerol found in certain cuts of GSC (Girl Scout Cookies), might benefit people who have a skin-crawling urge to protect themselves from everything. Whereas, CBD strains will be better when someone is feeling utterly defeated.


A patient’s story: A conversation with Chad Jackett of Cannabis Growers of Canada and Liberty Farms

Cannabis Life Network: What are your decisions when providing a patient, especially with heavy anxiety or PTSD?

Chad Jackett: It is patient specific. We like to start people off who don’t smoke or use cannabis with CBD to see if they get a response from that, before giving them an intoxicant. If it doesn’t help them then we can move on from there.

Liberty Cut Cookies is a special strain that is loaded with THC, contains a healthy portion of CBG, but has next to no CBD. Can you explain how people respond to this cut of GSC?

It does depend on the person, but it helps with their depression, their PTSD, and anxiety. It seems to minimize a lot of these psychological issues people are dealing with.

Beyond those terpenes, do you feel the CBG content in that profile is providing?

I do believe so. That is what everyone reports to us, so that is what we have come to believe.

Thank you for your time, Chad.

End of Conversation.


Defining depression and anxiety

Many variations of depression exist, some are even confused for anxiety. How cannabis treats a given symptom largely depends on your own system. Using the wrong variety might act as a bandaid without healing the underlying problem, such as a deficient endocannabinoid system. Although, this answer may take us through a web of reactions beyond just that alone.

Many believe in Cannabigerol’s therapeutic benefits on mood. Inhibiting a neurological need to survive is likely directed by re-uptake-inhibiting your endocannabinoids and GABA. In special cases, benefits can even come from mediating serotonin and noradrenaline.

Mental conditions are just menu options, pick and choose your flavour. What many of these names like anxiety and depression truly mean is a set of specific symptoms with their own characteristics.

CBG over Clonidine

The cannabinoid system can mediate eat, sleep, and protect, but it does not specifically lower the neurological fight-and-flight response. To lower the production of noradrenaline, CBG may benefit by agonizing a receptor known as Andreno-A2(a.)

This effect gives cannabigerol an asset in benefiting people with ADHD, dystonia, nervous-ticks, and temper more than anxiety. This effect might also be better for pain relief rather than relieving any neurological distress. In the end, though, that is all “patient-specific.”


Happiness and pitting serotonin

CBG continues to go beyond “canna” anything and dwells into the infamous realm of serotonin, the happiness-endorphin. ‘Serotonin re-uptake inhibitors‘ are common antidepressants – a group of widely consumed drugs used to alleviate depression.

Certain psychological distress can be subdued by serotonin and CBD. Unfortunately, some of these antidepressants take a long time for your body to adjust to them. Once they finally do, their effect will wear off over time. This could be due to your body countering the elevation of serotonin which leads people to start mega dosing, or giving up on CBD altogether.

Cannabigerol, a 5T1A antagonist, acts in opposition to anti-depressants like CBD. This can block the overall effect on the serotonin system. Cannabidiol and cannabigerol coupled together can prevent any action from occurring at the serotonin system, which would allow someone to utilize other effects more specifically.

Alternatively, at different doses and efficiencies, antagonizing the receptor can turn off your body’s response to shut down serotonin production. This will allow CBD to elevate serotonin without your body stopping it. This can aid the antidepressant effect of CBD for those that are no longer finding any relief or need relief immediately.

It is possible a little CBG can shorten that time and let the antidepressant effects kick in much faster. In truth though, cannabigerol’s exact mechanism is still being studied. Regardless, each to their own cannabinoid, it seems.

No anxiety: Gabbing with GABA

More of CBD and CBG’s ability to numb pain can also relax your mood. Many cannabinoids and terpenes are capable of acting as muscle relaxants. This is through one of your brains motherboards known as GABA. This transmitter blocks signalling and activity that not only responds to pain but also stress.

Cannabigerol and cannabidiol both raise the presence of GAGA. The end result is pain melting away and the mind-calming down. Unlike serotonin and noradrenaline, the affinity towards GABA is directly connected to the cannabinoid system.

Cannabinoids inside and out

We previously reported the different ways CBG and CBD strains interact with you. Two different internal cannabinoids are elevated by either CBD or CBG.

Unlike CBD and anandamide, a CBG facilitated elevation of your internal cannabinoid 2-AG will mediate your urge to protect yourself more than bring you joy. Similar to how THC can suit one person despite causing someone else to feel incredibly uncomfortable, 2-AG may also not be everyone’s friend.

It can lower your brains signalling which can bring intense mental calm, however, it works best when a neurological balance is achieved. Whether this is balance is achieved with anandamide or some other complex structure.

A full-spectrum

Given this balance, perhaps the terpene profile in Liberty Cut Cookies is quite important after all. Cookie strains typically come fairly dominating in the earthy Caryophyllene.

This ‘Liberty Cut’ has sweet, floral tones embracing the more robust cookies forward profile. All the more delightfully uplifting, but the therapeutic might will be in the caryophyllene. This terpene directly agonizes a cannabinoid receptor which will bring balance to CBG, 2-AG, and even THC.

A balance that runs from your limbic system all the way into the fibres firing signals into your muscles. Nervous twitches, tightness in your chests, face, and hands will all melt away. You will stop desperately trying to swim to a surface of safety that you already float on. Ultimately, your fears will wash away.

Never an isolated effect

Interestingly, is how these functions may all work in correlation. These effects may act as physical and neurological weave, giving CBG a nemesis status against mental distress for some individuals. Although, CBD or other terpenes might have to be involved as well. If they aren’t already a solo ticket to relief for you specifically.

Some of these effects have assets in other avenues of relief, such as pain and muscle relaxation. CBG is also an incredible mediator of inflammation, a story we will explore next in this “CBG” series.

Photo Courtesy of Cannabis Culture.

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